myrtecaine

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H302：삼키면 유해함

  H315：피부에 자극을 일으킴

  H411：장기적 영향에 의해 수생생물에 유독함

• 예방조치문구

  P264：취급 후에는 손을 철저히 씻으시오.

  P264：취급 후에는 손을 철저히 씻으시오.

  P270：이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.

  P280：보호장갑/보호의/보안경/안면보호구를 착용하시오.

  P301+P312：삼켜서 불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.

  P302+P352：피부에 묻으면 다량의 물로 씻으시오.

  P321：(…) 처치를 하시오.

  P330：입을 씻어내시오.

  P332+P313：피부 자극이 생기면 의학적인 조치· 조언을 구하시오.

  P362：오염된 의복을 벗고 세척 후에 재사용하기

  P501：...에 내용물 / 용기를 폐기 하시오.

myrtecaine 화학적 특성, 용도, 생산

• Originator

  Myrtecaine,Chemical Land21

• Manufacturing Process

  60 g (1.5 mol) of powdered sodium amide are put in suspension in 800 ml of toluene. The mixture is heated to 60°C and 166 g of homomyrtenol (1 mol) are added little by little. The reaction is continued for several hours until the homomyrtenol is entirely converted into sodium derivative. It is allowed to stand and the excess amide is filtered. The reaction is followed by titration on a sample of the decanted liquid after having removed the ammonia.
  Added to the solution of the sodium derivative of the terpenic alcohol (1 mol) is a toluenic solution of 138 g (1.02 mol) diethylaminochloroethane in toluene. This mixture is refluxed in a nitrogen atmosphere for 12 hours. A precipitate of sodium chloride is formed which is dissolved in water. Two modes of extraction of the base myrtecaine are possible:
  A) The toluenic solution is extracted with two times 200 ml of concentrated hydrochloric acid diluted to 20%. ln this way there is obtained an aqueous solution of the hydrochloride, when the required amino base is salted out by addition of potassium carbonate. The amino ether-oxide is finally rectified under a vacuum. The fraction boiling between 135° and 140°C under 2 to 3 mm is collected; nD20 = 1.477.
  B) The toluenic solution is dried on potassium carbonate and then rectified. There is collected the toluene, then between 120° and 130°C under 2 mm the homomyrtenol which has not reacted, and then between 130° and 145°C a fraction which is again fractionated. The pure product is collected at 135°- 140°C/2-3mm Hg.

• Therapeutic Function

  Local anesthetic, Spasmolytic

myrtecaine 준비 용품 및 원자재

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