N,N',N''-TRIACETYLCHITOTRIOSE

한글명:N,N',N''-TRIACETYLCHITOTRIOSE

카스 번호38864-21-0

상품명:N,N',N''-TRIACETYLCHITOTRIOSE

CBNumberCB4774136

분자식C24H41N3O16

포뮬러 무게627.59

MOL 파일38864-21-0.mol

화학적 성질

녹는점	271-272°C dec.
끓는 점	1146.9±65.0 °C(Predicted)
밀도	1.54±0.1 g/cm3(Predicted)
저장 조건	−20°C
용해도	H₂O: 50 mg/mL, 투명하거나 약간 흐릿함, 무색 내지 희미한 노란색
물리적 상태	고체
물리적 상태	단단한 모양
산도 계수 (pKa)	12.72±0.70(Predicted)
색상	흰색에서 옅은 베이지까지
수용성	water: 50mg/mL, clear to slightly hazy, colorless to faintly yellow
BRN	75249

위험 및 안전 성명

안전지침서	24/25
WGK 독일	3
F 고인화성물질	10-21
HS 번호	29329990

N,N',N''-TRIACETYLCHITOTRIOSE 화학적 특성, 용도, 생산

화학적 성질
Off-White Crystalline Solid
용도
N,N',N''-Triacetylchitotriose is a triose oligosaccharide derived from chitin, consisting of three N-acetylglucosamine units. It has been shown to scavenge reactive oxygen species and to protect DNA from oxidative damage.
화학 반응
The hydrolytic activity of lysozyme towards 4-methylumbelliferyl tetra-N-acetyl-β-chitotetraoside (4-MU-(GlcNAc)4) was little affected by ionic strength, though the activity of lysozyme towards cell suspension of Micrococcus lysodeikticus varied markedly with ionic strength. About 40-60percent of lysozyme activity with 4-MU-(GlcNAc)4 as a substrate was inhibited by 0.1 mM N,N',N''-triacetylchitotriose ((GlcNAc)3), but the lytic activity of lysozyme towards M. lysodeikticus was little affected. The kinetics of hydrolysis of 4-MU-(GlcNAc)4 by hen eggwhite (HEW) lysozyme and human placental (HP) lysozyme and the inhibition of this hydrolysis by (GlcNAc)3 were investigated. The K(s) values for 4-MU-(GlcNAc)4 of HEW- and HP-lysozymes were 19.7 and 27.9 μM, respectively, and the V(max) values were 0.124 and 0.0833 nmol/min/mg, respectively. The k values of both enzymes were very low, implying a poor orientation of the scissile bond in the substrate molecule with respect to the active site of lysozyme. (GlcNAc)3 inhibited lysozyme with hyperbolic mixed-type inhibition. The inhibition reduced V(max) values of both lysozymes. The K(s) value of HEW-lysozyme was increased by the addition of the inhibitory whereas the K(s) value of HP-lysozyme was decreased. The K(i) value was 29.6 μm for HEW-lysozyme and 106 μM for HP-lysozyme.
1. Hydrolysis of 4-methylumbelliferyl tetra-N-acetyl-β-chitotetraoside by lysozyme and its inhibition by N,N',N''-triacetylchitotriose
2. Tanimoto; Fukuda; Kawamura - Chemical and Pharmaceutical Bulletin, 1984, vol. 32, # 9, p. 3607 - 361

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