T0070907

한글명:T0070907

카스 번호313516-66-4

상품명:T0070907

CBNumberCB4771443

분자식C12H8ClN3O3

포뮬러 무게277.66

MOL 파일313516-66-4.mol

화학적 성질

녹는점	>184°C (dec.)
밀도	1.498
저장 조건	2-8°C
용해도	DMSO: >10mg/mL
물리적 상태	흰색 고체
색상	하얀색
수용성	10mg/ml의 DMSO에 용해됩니다. 물에 불용성.
감도	Light Sensitive

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

22-36

안전지침서

WGK 독일

HS 번호

29333990

NFPA 704:

	1
2		0

그림문자(GHS)

T0070907 화학적 특성, 용도, 생산

개요
The peroxisome proliferator-activated receptor-γ (PPARγ) is the nuclear receptor responsible for transducing the therapeutic activity of the thiazolidinediones (TZDs). TZDs are a group of structurally related synthetic PPARγ receptor agonists with antidiabetic actions in vivo. There are many PPARγ agonists, including 15-deoxy-Δ^12,14-prostaglandin J₂ and azelaoyl PAF, which are naturally derived. However, only a few antagonists have been reported. T0070907 is a potent and selective antagonist of the human PPARγ with an apparent IC₅₀ of 1 nM for the binding inhibition of rosiglitazone, a reference TZD. T0070907 covalently binds to Cys³¹³ of PPARγ, inducing conformational changes that block the recruitment of transcriptional cofactors to the PPARγ/RXR heterodimer.
화학적 성질
Off-White Solid
용도
T0070907 has been used to reduce peroxisome proliferator-activated receptor gamma (PPAR-γ) expression in lipopolysaccharide (LPS)-induced leukemia RAW264.7 cell line. It also has been used to evaluate the involvement of wogonin in alleviating EtOH (ethanol)-induced inflammation in RAW264.7 cell line.
일반 설명
T0070907 has antimicrotubule, antitumor and radiosensitizing properties. It decreases tubulin protein levels, which is associated with cell cycle arrest, apoptosis and also reduces metastasis of colorectal carcinoma cells. T0070907 is used as a therapeutic target in breast cancer. It stimulates proteasome-dependent degradation of tubulin.
생물학적 활성
Potent and selective PPAR γ antagonist (IC 50 = 1 nM). Displays > 800-fold selectivity for PPAR γ over PPAR α and PPAR δ . In vitro, blocks transcriptional activity of PPAR γ and inhibits rosiglitazone-induced adipogenesis.

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