엠제이33

엠제이33 화학적 특성, 용도, 생산

• 용도

  MJ33 lithium salt has been used as a peroxiredoxin VI (Prdx6) inhibitor:
  
  • to study its specific Prdx6 peroxidase activity in vitro and in breast cancer cell line (MCF-7) cell lysates
  • to study its effects on a mouse model of acute lung injury associated with exposure to hyperoxia
  • to study its potential use as a therapeutic agent
  
  

• Biochem/physiol Actions

  MJ33 acts as a non-toxic and potent inhibitor of agonist-induced activation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase type 2 (NOX2). It also prevents lung injuries associated with lung inflammation in mice. MJ33 is a fluorinated lipid analog, which blocks the enzyme by mimicking the transition state of the substrate.

엠제이33 공급 업체

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