다이티오-2,2'-비스피리딘-다이옥사이드 1,1'

한글명:다이티오-2,2'-비스피리딘-다이옥사이드 1,1'

카스 번호3696-28-4

상품명:Bispyrithione

CBNumberCB4500917

분자식C10H8N2O2S2

포뮬러 무게252.31

MOL 파일3696-28-4.mol

동의어(한글)

다이티오-2,2'-비스피리딘-다이옥사이드1,1'

화학적 성질

녹는점	200.5°C (rough estimate)
끓는 점	582.8±25.0 °C(Predicted)
밀도	1.4423 (rough estimate)
굴절률	1.5650 (estimate)
용해도	메탄올(약간 용해됨), 물(약간 용해됨, 가열, 초음파 처리)
물리적 상태	고체
물리적 상태	단단한 모양
산도 계수 (pKa)	-0.77±0.10(Predicted)
색상	Gray or off-white paste
수소이온지수(pH)	5.0-7.0(25°C,1%soln.)
안정성	흡습성
EPA	Dipyrithione (3696-28-4)

위험 및 안전 성명

HS 번호

2933399990

그림문자(GHS)

다이티오-2,2'-비스피리딘-다이옥사이드 1,1' 화학적 특성, 용도, 생산

개요
Bispyrithione is a pyrithione derivate used as bactericide and fungicide. The drug was marketed under the name Crimanex in the form of shampoo for the treatment of dandruff, however it is no longer available on the manufacturer website (Drossa Pharm . It is currently used as a pesticide.
화학적 성질
beige to slightly grey powder and chunks
용도
Bispyrithione can be used as an antibacterial; antifungal.
주요 응용
Bispyrithione is a new antidandruff agent behind zinc pyrithione. It has similar chemical structure to zinc pyrithione, thus performs the same bactericidal property, with unique bactericidal actions, especially to mycetes, mild fungus and microzymes. It also can effectively disinfect oval bacil, candia albicans and other mycetes, while normal antimicrobials can't. It is not sensitive to metal ion and dissolves in water more easily than zinc pyrithione, which improves the compatibility and leads to best bactericidal effect. In 2-in-1 shampoo, it doesn't affect the pearly effect but enhance color stability.
정의
ChEBI: Dipyrithione is a pyridinium ion.
Synthesis
1, drop into successively the 600g2-chloropyridine in the 5000ml four-hole boiling flask, 100g maleic and acid anhydrides, 600g hydrogen peroxide (35%) are opened to stir and are warmed up to 60 ℃ of successive reactions 12 hours, make 2-chloropyridine-N-oxide water solution.
2, the 2-chloropyridine that uses the 4000g2-methyl chloride to divide four extractions to make-N-oxide water solution merges extraction phase, and condensing crystal makes sterling 2-chloropyridine-N-oxide compound.
3, the 2-chloropyridine that purification is obtained-N-oxide compound, 430g sodium sulphite, the 2000g high purity water, drop into successively in the 5000ml four-hole boiling flask, open and stir, be warming up to 70 ℃, along with the carrying out of reaction added a part of yellow soda ash in good time, the PH of adjustment system is stabilized in 9～10, and reaction finishes 70 ℃ of insulations 2 hours, and insulation finishes to cool.Make the pyrithione sodium water solution.
4, use an amount of dilute sulphuric acid to adjust the PH to 2 of pyrithione sodium water solution system, separate out a large amount of white crystals.Filtrated stock cleans solid, namely gets pyrithione.
5, the pyrithione that the reaction of upper step is obtained, the 1000g ultrapure water drops in the plastic cup, the unlatching dispersed with stirring is even, then slowly splash into 220g hydrogen peroxide (35%), reaction is 1 hour about 50 ℃, make finished product Bispyrithione 497g (99.72%, five step of content overall yield of reaction: 74.6%).

다이티오-2,2'-비스피리딘-다이옥사이드 1,1' 준비 용품 및 원자재

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