메타피릴렌

한글명:메타피릴렌

카스 번호91-80-5

상품명:METHAPYRILENE

CBNumberCB4500689

분자식C14H19N3S

포뮬러 무게261.38576

MOL 파일91-80-5.mol

동의어(한글)

메타피릴렌

메타피릴렌및그염류

화학적 성질

녹는점	25°C
끓는 점	bp0.45 125-135°; bp3 173-175°
밀도	1.1388 (rough estimate)
굴절률	nD25 1.5842 (also reported as 1.5835)
저장 조건	Refrigerator, under inert atmosphere
용해도	DMSO(적게), 메탄올(약간)에 용해됨
물리적 상태	기름
산도 계수 (pKa)	pKa 3.02 ± 0.05;8.24± 0.11(H2O,t undefined,I=0.30(NaCl)) (Uncertain)
색상	무색~연황색
수용성	601.2mg/L(30℃)
안정성	안정적인. 강한 산화제와 호환되지 않습니다.
EPA	Methapyrilene (91-80-5)

위험 및 안전 성명

유엔번호(UN No.)	1851
위험 등급	6.1(b)
포장분류	III
유해 물질 데이터	91-80-5(Hazardous Substances Data)
독성	LD50 in mice, guinea pigs (mg/kg): 182.2 ±12.8, 374.9 ±34.5 orally; in mice (mg/kg): 19.85 ±0.69 i.v. (Lee)

그림문자(GHS)

메타피릴렌 화학적 특성, 용도, 생산

화학적 성질
colourless liquid
용도
Methapyrilene is an intermediate in the synthesis of Methapyrilene Hydrochloride (M259970). Methapyrilene is used as antihistaminic agent.
정의
ChEBI: A member of the class of ethylenediamine derivatives that is ethylenediamine in which one of the nitrogens is substituted by two methyl groups, and the other nitrogen is substituted by a 2-pyridyl group and a (2-thienyl)methyl group.
World Health Organization (WHO)
Methapyrilene, an antihistamine with moderate sedative activity, was introduced in 1947 for the treatment of various allergic conditions and was subsequently incorporated in many over-the-counter sleeping aids. In the early 1970s it was identified as a carcinogen in rats and, although there was no direct evidence that it constitutes a health hazard to man, it was withdrawn in many countries. (Reference: (WHODI) WHO Drug Information, 2, 4, 1979)
일반 설명
Clear colorless liquid.
반응 프로필
An amine, organosulfide. Organosulfides are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
건강위험
ACUTE/CHRONIC HAZARDS: METHAPYRILENE is highly toxic by ingestion.
화재위험
Flash point data for METHAPYRILENE are not available, but METHAPYRILENE is probably combustible.
신진 대사 경로
When methaphenilene is incubated with rat liver microsomes, it is metabolized via N-oxide formation and N-dealkylation which includes removal of the dimethylamino moiety, the thiophenylmethyl moiety of methaphenilene, and the benzyl moiety of pyribenzamine.

메타피릴렌 준비 용품 및 원자재

메타피릴렌 공급 업체

Send Inquriy