8-bromo-Cyclic ADP-Ribose (sodium salt)

8-bromo-Cyclic ADP-Ribose (sodium salt) 화학적 특성, 용도, 생산

• 개요

  Cyclic ADP-ribose (cADP-ribose) is a calcium mobilizing nucleotide that is biosynthesized from NAD⁺ by cADP-ribose synthases, including CD38. cADP-Ribose appears to activate calcium channels in intracellular membranes, which in turn activate ryanodine receptors. 8-bromo-cADP-Ribose is a stable, cell-permeable analog that blocks calcium release evoked by cADP-ribose in sea urchin egg homogenates with an IC₅₀ value of 1.7 μM. It is commonly used to investigate intracellular signaling through cADP-ribose in isolated cells and tissues.

8-bromo-Cyclic ADP-Ribose (sodium salt) 공급 업체

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