1-Oleoyl lysophosphatidic acid sodium salt

1-Oleoyl lysophosphatidic acid sodium salt 화학적 특성, 용도, 생산

• 용도

  Oleoyl-L-α-lysophosphatidic Acid reduces the organ injury caused by endotoxemia in the rat.?It may be useful in the treatment of shock of various etiologies.

• 일반 설명

  Lysophosphatidic acid (LPA) is an essential metabolite for membrane biosynthesis. LPA interacts with the G protein-coupled receptors (GPCRs), called the LPA receptor and mediates signaling. Oleoyl-L-α-lysophosphatidic acid activates the receptor LPA4. In keratinocytes, oleoyl-L-α-lysophosphatidic acid promotes growth to some extent.

• Biochem/physiol Actions

  Endogenous agonist for LPA1 and LPA2 receptors. LPA does not induce angiogenesis, but has effects on endothelial cell physiology that are similar to those of sphingosine 1-phosphate. Induces cell migration of cancer and non-cancer cells.

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