포도풀수지

한글명:포도풀수지

카스 번호9000-55-9

상품명:PODOPHYLLUM RESIN

CBNumberCB4451718

분자식C88H92O34

포뮬러 무게1693.65168

MOL 파일9000-55-9.mol

동의어(한글)

포도풀수지

화학적 성질

저장 조건	2-8°C
물리적 상태	가루
색상	갈색
안정성	안정적인. 강한 산화제와 호환되지 않습니다.

위험 및 안전 성명

위험품 표기	T+
위험 카페고리 넘버	61-26/27/28-34
안전지침서	53-26-27-36/37/39-45
유엔번호(UN No.)	UN 2811 6.1/PG 2
WGK 독일	3
RTECS 번호	TP8925000

그림문자(GHS)

포도풀수지 화학적 특성, 용도, 생산

화학적 성질
light yellow to brown powder
용도
antiallergic
Indications
Podophyllin in a 10% to 25% suspension in a tincture of benzoin or alcohol can be used with success. Since this compound contains two mutagens, quercetin and kaempherol, it should used with caution in the physician’s office. It should stay on for 1 to 4 hours and be applied every week for 4 to 6 weeks. Podofilox (0.05 mL of 5%) is safer than podophyllin and should be self-applied twice a day for 3 days followed by 4 rest days to complete a treatment cycle. Topical 0.5% podophyllotoxin cream has been used b.i.d. for 3 consecutive days for a maximum of 4 weeks with clearance in 54% of patients. Podophyllum resin (podophyllin), or podofilox, a cytotoxic agent that arrests mitosis in metaphase, is used primarily for treatment of condyloma acuminata but may also be used on all other types of warts. Although now rarely available, a 25% preparation of podophyllum in compound tincture of benzoin should be applied overnight when treating common nongenital warts. A more commonly available preparation, podofilox 0.5% gel (Condylox), should be applied twice a day for 3 days, then discontinued for 4 consecutive days. The same cycle is continued until eradication of the lesions. The effectiveness as well as the irritant potential of this medication may be increased by covering with adhesive tape or plastic tape (Blenderm).
World Health Organization (WHO)
Podophyllum resin, which is extracted from Indian podophyllum, is highly irritant to the skin and mucous membranes and its use in purgatives is now obsolescent. However, topical preparations remain available for the treatment of venereal and other warts and the drug is included in the WHO Model List of Essential Drugs for this purpose. Podophyllin extracts have been demonstrated to have a teratogenic potential which has led to their withdrawal in some countries and restriction of use in others. They are best avoided during pregnancy. (Reference: (WHTAC1) The Use of Essential Drugs, 2nd Report of the WHO Expert Committee, 722, , 1985)
일반 설명
Podophyllin is an alcoholic plant extract, obtained from the dried rhizome and roots of?Podoplryllui emodi. It is a powder with colors varying from light brown to greenish-yellow and exposure to heat or light turns it darker.
Mechanism of action
Podophyllum resin (podophyllin) is a chemically complex extract obtained from the roots of either of the two plants: Podophyllum peltatum (American) or Podophyllum emodi (Indian) (also called Mandrake or May-apple). Podofilox is the most cytotoxic ingredient in podophyllum resin (present in concentrations of 15% to 20% in P. peltatum and 30% to 40% in P. emodi resins) and exerts its effect by binding to intracellular microtubular proteins and thereby preventing the development of the mitotic spindle. In vitro, podophyllum also inhibits RNA synthesis. Podophyllum is used in the treatment of condyloma acuminata and other warts.
부작용
Podophyllin can cause severe irritation and, if absorbed in large quantities, may produce systemic toxic effects. It is inadvisable to apply it in large amounts to mucous membranes, and it is unwise to use it in pregnant women because of its possible cytotoxic action on the fetus.
Safety Profile
Poison by ingestion, subcutaneous, and intraperitoneal routes. An irritant to skin, eyes, and mucous membranes. Questionable carcinogen with experimental neoplastigenic data. An experimental teratogen. Other experimental reproductive effects. Combustible when exposed to heat or flames. When heated to decomposition it emits acrid smoke and irritating fumes.

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