5'-데옥시-S-아데노실-L-호모시스테인

5'-데옥시-S-아데노실-L-호모시스테인 화학적 특성, 용도, 생산

• 개요

  S-Adenosyl-L-homocysteine (SAH) is an amino acid derivative and an intermediate, by-product, or modulator of several metabolic pathways, including the activated methyl cycle and cysteine biosynthesis. It is also a product of S-adenosyl-methionine (SAM)-dependent methylation of biological molecules, including DNA, RNA, and histones and other proteins. SAH is a risk factor for many diseases, including cancer and neurodegenerative diseases. In addition, inhibitors that block its hydrolysis are being developed as anti-viral, anti-parasitic, anti-arthritic and immunosuppressive agents.

• 화학적 성질

  Pale Beige Solid

• 용도

  A novel biomarker for predicting susceptibility of a subject to a mental or neurodegenerative disorder.

• 정의

  ChEBI: The S-adenosyl derivative of L-homocysteine.

• Purification Methods

  It has been recrystallised several times from aqueous EtOH or H2O to give small prisms and has max 260nm in H2O. The picrate has m 170o(dec) from H2O. [Baddiley & Jameison J Chem Soc 1085 1955, de la Haba & Cantoni J Biol Chem 234 603 1959, Borchardt et al. J Org Chem 41 565 1976, NMR: Follmann et al. Eur J Biochem 47 187 1974, Beilstein 26 III/IV 3676.]

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