β-Boswellic Acid

한글명:β-Boswellic Acid

카스 번호631-69-6

상품명:β-Boswellic Acid

CBNumberCB4427357

분자식C30H48O3

포뮬러 무게456.71

MOL 파일631-69-6.mol

화학적 성질

녹는점	130-135°C
알파	D +107° (c = 0.75 in CHCl3)
끓는 점	556.0±50.0 °C(Predicted)
밀도	1.09±0.1 g/cm3(Predicted)
저장 조건	Sealed in dry,2-8°C
용해도	클로로포름(약간 용해됨), 에틸아세테이트(약간 용해됨), 메탄올(약간 용해됨)
용해도	클로로포름(약간), 에틸아세테이트(약간), 메탄올(약간)에 용해됨
산도 계수 (pKa)	4.50±0.70(Predicted)
물리적 상태	Solid
색상	회백색
수용성	물에 거의 녹지 않음
InChIKey	NBGQZFQREPIKMG-AKOQEMLPSA-N
LogP	9.105 (est)
CAS 데이터베이스	631-69-6

위험 및 안전 성명

WGK 독일

NFPA 704:

	0
2		0

그림문자(GHS)

β-Boswellic Acid 화학적 특성, 용도, 생산

개요
β-Boswellic acid is a pentacyclic triterpene originally isolated from Boswellia that has diverse bioactivities. It inhibits 5-lipoxygenase (5-LO) with an IC₅₀ value of approximately 5 μM but is less potent than its derivative 3-acetyl-11-keto-β-boswellic acid . It inhibits cell proliferation in HL-60 cells with IC₅₀ values of 3.7, 7.1, and 6.3 μM for DNA, RNA, and protein synthesis, respectively. In human umbilical vein endothelial cells (HUVECs) transiently deprived of oxygen and glucose, β-boswellic acid increases nitric oxide and increases phosphorylation of enzyme nitric oxide synthase (eNOS). It also increases calcium mobilization in platelets at concentrations ≥3 μM and induces platelet aggregation (EC₅₀ = 8 μM).
화학적 성질
BETA-BOSWELLIC ACID is Off-White Solid
용도
The principal constitutents of frankincense (olibanum). A specific, nonredox inhibitor of 5-lipoxygenase used to treat inflammation.
Anticancer Research
It is a natural pentacyclic triterpenediol and occurs in Boswellia serrata plants as anisomeric blend of 3α, 24-dihydroxyolean-12-ene and 3α, 24-dihydroxyurs-12-ene.It induces apoptosis in various cancer cells. The events involved in this process areexcessive reactive oxygen species (ROS), nitric oxide (NO) formation, DNA ladderformation, and increased sub-G0 phase in cell cycle. This ultimately results incleavage of Bcl-2 and translocation of Bax to mitochondria, which lead to the lossof mitochondrial potential and release of cyt-c and other factors into cytosol. All these events are linked with reduced expression of survivin and inhibitor of caspase-activatedDNases (ICAD) that leads to the activation of poly(ADP-ribose) polymerase(PARP). The triterpene upregulates the expression of cell death receptor-4(DR-4) and tumor necrosis factor receptor-1 (TNF-R1), where both lead to activationof caspase-8 (Huang et al. 2000; Desai et al. 2008; Lu et al. 2008).

β-Boswellic Acid 공급 업체

β-Boswellic Acid 관련 검색

Send Inquriy