바쿠치올

한글명:바쿠치올

카스 번호10309-37-2

상품명:Bakuchiol

CBNumberCB4365255

분자식C18H24O

포뮬러 무게256.38

MOL 파일10309-37-2.mol

동의어(한글)

바쿠치올

피치팜열매즙

4-(XNUM-DIMETYLY-3,7-VINYL-OCTA-3-DIENYL)-페놀

화학적 성질

끓는 점	391℃
밀도	0.963
증기압	0Pa at 25℃
굴절률	1.4500 (estimate)
인화점	177℃
저장 조건	Inert atmosphere,Store in freezer, under -20°C
용해도	DMSO(최대 25mg/ml) 또는 에탄올(최대 20mg/ml)에 용해됩니다 에 용해됨
물리적 상태	Liquid
산도 계수 (pKa)	10.10±0.26(Predicted)
색상	오일과 같은 색상
optical activity	[α]/D +24.0 to +30.0°, c = 0.1 in chloroform
BRN	3611720
안정성	제공된 대로 구매일로부터 1년 동안 안정적입니다. DMSO 또는 에탄올 용액은 -20°C에서 최대 1개월 동안 보관할 수 있습니다.
InChIKey	LFYJSSARVMHQJB-WYMLVPIESA-N
LogP	5.09 at 20℃ and pH6.31
표면장력	43.92mN/m at 1g/L and 20℃

위험 및 안전 성명

WGK 독일	3
RTECS 번호	SL3785000
독성	LD50 orl-mus: 2560 mg/kg MZHUDX 42,646,80

그림문자(GHS)

바쿠치올 화학적 특성, 용도, 생산

개요
Bakuchiol (10309-37-2) is a natural terpenoid antioxidant.It has the follow effects: 1.Inhibits oxidative stress-induced decrease in mitochondrial membrane potential and associated release of pro-apoptotic factors.2.Protects against acute lung injury.3.Displays neuroprotective and anti-inflammatory effects.
용도
(S)-Bakuchiol is a meroterpen found in the medicinal resinous shrub Psoralea glandulosa. An analogue of Resveratrol (R150000) with antifungal and anti-tumor effects. Studies have shown that Bakuchiol is a potent cytotoxic agent that exhibiting concentration dependent growth inhibition against leukemia cancer cells.
생물학적 활성
Bakuchiol (BAK) has various pharmacological effects such as antioxidant, anti-aging, anti-inflammatory, antimicrobial, antidiabetic, cardioprotective, and estrogen-like effects. BAK exhibits antimicrobial activity against oral microorganisms such as Streptococcus mutans. It is also a DNA polymerase inhibitor and showed anti-tumour activity in human lung adenocarcinoma A549 cells. BAK showed hepatoprotective activity in vitro and in vivo against liver injury in rats.
Safety Profile
Poison by intravenous andintraperitoneal routes. Moderately toxic by ingestion.When heated to decomposition it emits acrid smoke andfumes.
Mode of action
The research found that BAK upregulates the expression of the antiapoptotic molecule Bcl2 and downregulates the expression of the proapoptotic molecules Bax and caspase-3 by activating the silent information regulator 1 (SIRT1) signaling pathway and thereby inhibits mitochondrial damage and ameliorates myocardial IRI. BAK promotes apoptosis in hepatic astrocytes through the caspase-3-dependent pathway and inhibits liver fibrosis. In addition, BAK exerts a protective effect against hepatotoxicity induced by tert-butyl hydroperoxide (tBH), tetrachloromethane (CCl4), and d-galactosamine (D-GalN). BAK (60?mg/kg) treatment significantly reduces edema and pathological changes in lung tissues by inhibiting intense inflammation and exerting protective effects in the lung under sepsis conditions[5-6].

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