PARP

PARP 화학적 특성, 용도, 생산

• 용도

  PARP-1 is a nuclear enzyme that synthesizes ADP-ribose polymers from NAD⁺, specifically binds Zn²⁺ and DNA, and recognizes single-strand breaks in DNA. PARP1 has been used in a study to assess racial and tissue-specific cancer risk associated with polymorphism in the PARP1 gene. It has also been used in a study to investigate inhibitors of PARP-1 for potential cancer treatments.

• 일반 설명

  Poly(ADP-ribose) polymerase 1 (PARP-1) is associated with the inflammation response during atherosclerosis.

• Biochem/physiol Actions

  PARP-1 is inactivated by cleavage into a 24kDA and 89kDA fragment by activated caspase-3 or caspase-7. This results in the decreased ability to repair DNA damage and an increase in apoptosis.

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