4-Hydroxyalternariol

4-Hydroxyalternariol 화학적 특성, 용도, 생산

• 개요

  4-hydroxy Alternariol is a metabolite of the mycotoxin alternariol formed through cytochrome P450 (CYP450) metabolism. It increases reactive oxygen species (ROS) in KYSE510 human esophageal cells by 701% compared to control. 4-hydroxy Alternariol increases topoisomerase IIβ-DNA complexes by 208% compared to control in an ICE assay but does not induce DNA damage in KYSE510 cells. It completely inhibits topoisomerase IIα activity at a concentration of 25 μM under cell-free conditions.

• 용도

  4-Hydroxyalternariol is the fully demethylated tetraphenol analogue of the benzopyranone graphislactones. Hydroxyalternariol was isolated as a major co-metabolite of a graphislactone A-producing fungus. Hydroxyalternariol has not previously been available for study and no bioactivity has been reported to date.

4-Hydroxyalternariol 공급 업체

Global(11)Suppliers