2-[3-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-propylsulfanyl]-benzoic acid

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H302：삼키면 유해함

  H410：장기적 영향에 의해 수생생물에 매우 유독함

• 예방조치문구

  P264：취급 후에는 손을 철저히 씻으시오.

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2-[3-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-propylsulfanyl]-benzoic acid 화학적 특성, 용도, 생산

• 개요

  GRI-977143 is an agonist of G protein-coupled lysophosphatidic acid receptor 2 (LPA₂) with an EC₅₀ value of 3.3 μM in LPA₂-transfected RH7777 cells. It is selective for LPA₂, having no activity at LPA₁, LPA₃, LPA₄, and LPA₅ at concentrations up to 10 μM. GRI-977143 increases growth and reduces caspase-3 and -7 activation in LPA₂-transduced MEF fibroblasts. It increases MM1 rat hepatoma cell invasion and inhibits apoptosis of IEC-6 cells induced by TNF-α, doxorubicin , or serum withdrawal. GRI-977143 also rescues apoptotic cells from γ-irradiation-induced injury in vitro and in vivo.

• 용도

  2-[3-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-propylsulfanyl]-benzoic acid is used as a non-lipid agonist of LPA2. LPA (Lipoprotein Associated Phospholipase A2/A3 are important factors in prediction of diseases involving fatty acids such as coronary heart disea se or atherosclerosis.

2-[3-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-propylsulfanyl]-benzoic acid 공급 업체

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