HPI-1수화물

HPI-1수화물 화학적 특성, 용도, 생산

• 개요

  HPI-1 (hydrate) is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Sonic Hh (IC₅₀ = 1.5 μM) without significantly affecting Wnt signaling (IC₅₀ ≥ 30 μM). HPI-1 suppresses Hh activation induced by loss of Suppressor of Fused or by Gli overexpression, suggesting action at posttranslational modification of Gli protein or at the interaction of Gli with a co-factor. HPI-1 (hydrate) also inhibits signaling through the oncogenic Smoothened (Smo) mutant SmoM2 in neuron precursors, preventing cell proliferation.

• 용도

  HPI-1 is a Hedgehog pathway inhibitor; Gli1/Gli2 inhibitor.

HPI-1수화물 공급 업체

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