PSYCHOSINE

한글명:PSYCHOSINE

카스 번호2238-90-6

상품명:PSYCHOSINE

CBNumberCB4245038

분자식C24H47NO7

포뮬러 무게461.63

MOL 파일2238-90-6.mol

화학적 성질

녹는점	190 °C (decomp)
끓는 점	664.3±55.0 °C(Predicted)
밀도	1.14±0.1 g/cm3(Predicted)
저장 조건	-20°C
용해도	Chloroform/Methanol/DI water (5:1:0.1): soluble; Ethanol: soluble
물리적 상태	동결건조된 분말
산도 계수 (pKa)	11.74±0.45(Predicted)
색상	White to off-white

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

20/21/22

안전지침서

WGK 독일

NFPA 704:

	0
3		0

그림문자(GHS)

PSYCHOSINE 화학적 특성, 용도, 생산

개요
Galactosylsphingosine is a bioactive sphingolipid. It potentiates LPS-induced production of inflammatory cytokines, decreases the mitochondrial membrane potential, and induces cell death in mouse astrocytes, effects that can be reversed by the sphingosine-1-phosphate receptor agonist FTY720 phosphate . Galactosylsphingosine (0.1 and 1 μM) induces demyelination of mouse cerebellar slices. It inhibits PDGF-induced translocation of PKC to the cell surface and induces apoptosis in MO3.13 oligodendrocytes. Galactosylsphingosine (10 and 15 μM) inhibits gene transcription mediated by peroxisome proliferator-activated receptor α (PPARα) in reporter assays using C6 glial cells. Levels of galactosylsphingosine are increased in postmortem brain from patients with Krabbe disease, a lysosomal storage disorder characterized by a β-galactosylceramidase deficiency.[Matreya, LLC. Catalog No. 1305]
용도
Psychosine is a cationic lysosphingolipid that displays neuroprotective effects against quisqualate.
정의
ChEBI: A glycosylsphingoid consisting of sphingosine having a beta-D-galactosyl residue attached at the 1-position.
일반 설명
Galactosyl(β) Sphingosine (d18:1) is a substrate for the enzyme endoglycoceramidase I (EGCase I). It has sphingosine backbone with galactose attached to it and is a brain glycospingolipid.
효소 저해제
This cationic brain lysosphingolipid (FWfree-base = 461.64 g/mol; CAS 2238- 90-6), also known as 1-O-b-D-galactosylsphingosine, inhibits metabotropic a1-adrenergic receptor signaling-induced phospholipase C activation in rat brain astrocytes. Psychosine also exerts protective effects against quisqualate, suggesting it may be useful in prophylaxis of neurodegenerative disorders arising from over-stimulation of hippocampal Group 1 metabolotropic glutamate receptor, or mGluR. Psychosine is the product of the reaction catalyzed by sphingosine b-galactosyltransferase and is the substrate for psychosine sulfotransferase and galactosylceramidase. Target(s): cerebroside-sulfatase, or arylsulfatase A; cytochrome c oxidase; cytokinesis; electron transport; galactosylgalactosylglucosylceramidase; glucocerebrosidase, lysosome; b-glucosidase; phosphorylase kinase; protein kinase C (11- 14); protein-tyrosine sulfotransferase; and sphingomyelinase.

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