양명아주

양명아주 화학적 특성, 용도, 생산

• 화학적 성질

  Colorless or yellowish oil; characteristic penetrating odor; bitterish burning taste. Soluble in 3–10 volumes of 70% alcohol (inferior and adulterated oils do not yield a clear solution).

• 출처

  Found in the flowers and fruit of the plant C. ambrosioides and C. ambrosioides L. var. anthelminticum (L.) A. Gray (Fam. Chenopodiaceae) (Guenther, 1952).

• 용도

  Chenopodium Oil may cause an increase in the erythrocyte count by provoking contraction of the spleen. Chenopodium Oil has been used for the treatment of strongylidosis in horses.

• 제조 방법

  By steam distillation from the overground parts of the flowering and fruiting plant, C. ambrosioides (Guenther, 1952).

• Pharmacology

  In tests of antispasmodic activity, a saturated aqueous solution of chenopodium oil showed musculotropic spasmolytic activity against BaCl2-induced spasms in rat duodenum, had a clear antihistaminic action in guinea-pig ileum and inhibited nicotine-induced spasms in rabbit jejunum (Debelmas & Rochat, 1967). Frogs, toads and guinea-pigs responded to chenopodium oil by a decrease in the rate and amplitude of the heart beat, ascribed to vagus excitation and myocardium intoxication (Donatelli, 1935).

• 신진 대사

  The oil is readily absorbed from the gastro-intestinal tract. It is partially eliminated in the lungs, but excretion via the urine or faeces does not appear to have been reported (Goodman & Gilman, 1960). Traces of ascaridole were found in the stomach and intestinal tract of a 14-monthold baby who died from poisoning with chenopodium oil (Meie, 1952).

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