봉크렉산

한글명:봉크렉산

카스 번호11076-19-0

상품명:BONGKREKIC ACID

CBNumberCB4140241

분자식C28H38O7

포뮬러 무게486.6

MOL 파일11076-19-0.mol

동의어(한글)

봉크렉산

화학적 성질

녹는점	50-60°
알파	D25 +162.5°
끓는 점	715.1±60.0 °C(Predicted)
밀도	1.114±0.06 g/cm3(Predicted)
저장 조건	-20°C
용해도	DMSO(최대 100mg/ml) 또는 물(최대 1mg/ml)에 용해됩니다.
물리적 상태	동결건조된 고체
산도 계수 (pKa)	4.15±0.10(Predicted)
색상	Colorless to light yellow
안정성	제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO 또는 증류수 용액은 -20°에서 최대 3개월 동안 보관할 수 있습니다.

위험 및 안전 성명

WGK 독일	-
유해 물질 데이터	11076-19-0(Hazardous Substances Data)
독성	LD50 i.v. in mice: 1.41 mg/kg (Lijmbach)

봉크렉산 화학적 특성, 용도, 생산

용도
Bongkrekic acid solution has been used as an adenine nucleotide translocator (ANT) inhibitor to find out a different approach for the inhibition of oxidative phosphorylation in intact T98G cells. It has also been used as an inhibitor of the permeabilization transition pore complex (PTPC) pore and a tool to explore the role of PTPC in induction of apoptosis.
정의
ChEBI: A tricarboxylic acid that is docosa-2,4,8,10,14,18,20-heptaenedioic acid substituted at positions 2 ,5 and 17 by methyl groups, at positions 6 by a methoxy group and at position 20 by a carboxymethyl group.
효소 저해제
This toxic tricarboxylic acid (FWfree-acid = 486.61 g/mol; CAS 11076-19-0), produced Pseudomonas cocovenenans, is a potent competitive inhibitor of the mitochondrial ATP-ADP translocator, effectively blocking nucleotide binding to the carrier. The name is derived from bongkrek, a moldy coconut product produced in Indonesia. The toxin accumulates when P. cocovenenans outgrows the mold. Klingenberg et al. investigated bongkrekate binding to mitochondrial membrane to examine the reorienting site mechanism. The inferred mode of inhibition requires bongkrekate to bind to the single carrier site only from the inner face of the mitochondrial membrane (i.e., the matrix side)). They confirmed the pH-dependent accumulation of [3H]bongkrekate inside the mitochondria which superimposes onto the binding at carrier sites. By breaking the membrane with Lubrol or sonication, binding to the carrier sites could be titrated, and a Kd value of approximately 5 x 10–8 M was determined. The presence of ADP or ATP increases the amount of binding but does not alter the Kd. [35S]Atractylate is displaced by [3H]bongkrekate at a 1:1 molar ratio; this displacement is dependent on ADP concentration with the Km = 0.5 x 10–6 M. See also Atractyloside The isomer known as isobongkrekic acid, which has a cis-double bond at the dicarboxylic acid end of the molecule, has similar biological activity. Target(s): Adenine nucleotide translocator, ADP/ATP carrier; ATPase; bromelain, stem; papain; ficain, or ficin.

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