코부시네

코부시네 화학적 특성, 용도, 생산

• 개요

  Obtained by Suginome and Shimanouti from the precipitation liquors of crude jesaconitine from Aconitum sachalinense, Fr. Schmidt, this alkaloid crystallizes from Me2CO in the rhombic-bisphenoidal system and has (a:b:c = 1.0736: I: 0.9811). It furnishes crystalline salts: the hydrobromide crystallizes as the mono_x0002_hydrate, m.p. 288°C (dec.); [α]²²_D + 40.68° (H20); hydrochloride (1.5 H20) has m.p. 300°C (dec.);[α]²¹_Dl + 41.4° (H20); perchlorate, m.p. 185-7°C (dec.) although a value of 220°C has also been recorded for this salt; platinichloride, m.p. 262°C (dec.); picrate, m.p. 282-4°C (dec.) and methiodide, m.p. 287°C (dec.). The alkaloid forms a diacetyl derivative, m.p. 139-140°C and catalytic reduction followed by acetylation yields a triacetyltetrahydrokobusine, m.p. 183-4°C (dec.). The alkaloid cannot be hydrolyzed and is non-toxic.

• 참고 문헌

  Suginome, Shimanouti., Annalen, 545, 220 (1940)
  Okamoto., Chern. Pharm. Bull. (Tokyo), 7,44 (1959)
  Natsume., ibid, 7,539 (1959)

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