2-METHYLISONICOTINALDEHYDE

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H302：삼키면 유해함

  H315：피부에 자극을 일으킴

  H319：눈에 심한 자극을 일으킴

  H335：호흡 자극성을 일으킬 수 있음

• 예방조치문구

  P261：분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.

  P305+P351+P338：눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

2-METHYLISONICOTINALDEHYDE 화학적 특성, 용도, 생산

• 용도

  2-Methylisonicotinaldehyde belongs to the pyridine group of compounds and is used in the preparation of benzimidazoles and related analogues as sirtuin modulators and in the synthesis of other organic compounds.

• Synthesis

  2-Methylisonicotinaldehyde is synthesised using methanol as raw material by chemical reaction. The specific synthesis steps are as follows:
  A solution of N,N-dimethyl-2-(2-methyl-4-pyridyl)ethenamine (6.4 g, 39 mmol) in methanol (25 ml) was added dropwise to a mixture of sodium periodate (25.2 g, 117 mmol) and methanol (25 ml) at room temperature.. The mixture was stirred at the same temperature for 1 hr.. The precipitates were filtered off, and the filtrate was concentrated.. The residue was combined with water and extracted with ethyl acetate.. The organic layer was washed with saturated brine and dried over magnesium sulfate.. The solvent was evaporated to give the titled compound (3.7 g, 78 percent).1H-NMR (CDCl3) δ: 2.68 (3H, s), 7.51 (1H, d, J = 4.9 Hz), 7.56 (1H, s), 8.76 (1H, d, J = 4.9 Hz), 10.05 (1H, s).
  

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