앰베노늄

앰베노늄 화학적 특성, 용도, 생산

• 정의

  ChEBI: A symmetrical oxalamide-based bis-quaternary ammonium ion having ethyl and 2-chlorobenzyl groups attached to the nitrogens.

• 상표명

  Mytelase (Sanofi Aventis).

• Pharmacology

  The pharmacological properties of ambenonium are similar to neostigmine and pyridostigmine, and it works by reversible inactivation of cholinesterase.

• Synthesis

  Ambenonium, [oxalyl-bis-(iminoethylen)]-bis-[ortho-(chlorobenzyl) diethylammonium] chloride (13.2.15), is made by reacting diethyloxalate with two moles of N,N-diethylethylendiamine, forming oxalyl-bis-(iminoethylen)-bis-N,N-diethylamine (13.2.14), which is alkylated by two moles of 2-chlorobenzylchloride, giving ambenonium (13.2.15) [46¨C48].

  

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