PROCATEROL HYDROCHLORIDE

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

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PROCATEROL HYDROCHLORIDE 화학적 특성, 용도, 생산

• 개요

  Procaterol is an agonist of β₂-adrenergic receptors (β₂-ARs). It binds to (K_d = 46 pM), and is selective for, β₂-ARs over β₁-ARs (K_d = 4,000 pM). Procaterol binds more potently to β₂-ARs in isolated guinea pig lung than to β₁-ARs in isolated guinea pig cardiac ventricle in the presence (IC_50s = 175 and 1,660 nM, respectively) and absence of GTP (; IC₅₀s = 55.1 and 1,660 nM, respectively). It inhibits contractions induced by acetylcholine in isolated guinea pig trachea (EC₅₀ = 10.5 nM). In vivo, procaterol inhibits histamine-induced airflow obstruction in a guinea pig model of ovalbumin-sensitized asthma when administered via inhalation at a dose of 10 μg/ml.

• 용도

  Procaterol Hydrochloride is a short-acting pulmonary β2-agonist for asthma treatment.

• 일반 설명

  Procaterol is used to prevent lung fibroblast migration. It has anti-inflammatory properties. It can block type 2 T helper (Th2)-related chemokine production in human monocytes and bronchial epithelial cells.

• 생물학적 활성

  Specific and very potent β 2 agonist.

PROCATEROL HYDROCHLORIDE 공급 업체

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