에포에틴알파

에포에틴알파 화학적 특성, 용도, 생산

• 용도

  Anti-anemic; hematinic.

• 일반 설명

  Epoetin alfa, rEPO (Epogen, Procrit), isthe recombinant human erythropoietin produced in Chinesehamster ovary cells into which the human erythropoietin genehas been inserted. These mammalian cells glycosylate theprotein in a manner similar to that observed in human cells.
  Epoetin alfa is indicated in anemic patients with chronicrenal failure, including both those who require regular dialysisand those who do not. Epoetin alfa is also indicated inanemia associated with AIDS, treatment of AIDS with zidovudine,frequent blood donations, and neoplastic diseases.It is indicated to prevent anemia in patients who donateblood prior to surgery for future autologoustransfusions and to reduce the need for repeated maintenancetransfusions. The hormone is available as an isotonicbuffered solution, which is administered by the intravenousroute. The solution should not be frozen or shakenand is stored at 36°F to 46°F.

• Clinical Use

  Epoetin Alfa, recombinant Erythropoietin alfa, Epogen,Procrit, is a glycoprotein that stimulates red blood cellproduction. It is produced in the kidney, and it activates theproliferation and differentiation of specially committed erythroidprogenitors in the bone marrow.
  Epoetin is indicated to treat anemia of chronic renal failurepatients, anemia in zidovudine-treated HIV-infectedpatients, and in cancer patients taking chemotherapy. Theresults in these cases have been dramatic; most patients respondwith a clinically significant increase in hematocrit.

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