RP-8-브로모-베타-페닐-1,N2-에테노구아노신3',5'-환상모노포스포로티오에이트나트륨염수화물

RP-8-브로모-베타-페닐-1,N2-에테노구아노신3',5'-환상모노포스포로티오에이트나트륨염수화물 화학적 특성, 용도, 생산

• 개요

  Rp-8-bromo-PET-Cyclic GMPS (Rp-8-bromo-PET-cGMPS) is an analog of cyclic GMP (cGMP). It is a cell permeable, competitive, and reversible inhibitor of cGMP-dependent protein kinases (cGKs) that blocks activation of cGKI and cGKII by cGMP (K_is = 35 and 30 nM). It less potently inhibits protein kinase A (K_i = 11 μM) and cGMP-induced activation of cyclic nucleotide-gated channels (IC₅₀ = 25 μM). In the absence of cGMP stimulation, Rp-8-bromo-PET-cGMPS can act as a partial agonist of cGKI (K_i = 1 μM). Rp-8-bromo-PET-cGMPS is resistant to hydrolysis by phosphodiesterase 11.

• 용도

  Rp-8-Br-PET-cyclic GMPS Sodium Salt is a competitive inhibitor of cGMP-dependent protein kinase (cGKI).

• Biochem/physiol Actions

  Rp-8-Br-PET-cGMPS is metabolically stable, competitive inhibitor of cGMP-dependent protein kinase G. Inhibits both PKG I (Ki?=?30 nM) and PKG II and blocks cGMP-gated retinal type ion channels (IC50?=?25 micromoles).

RP-8-브로모-베타-페닐-1,N2-에테노구아노신3',5'-환상모노포스포로티오에이트나트륨염수화물 공급 업체

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