에타미필린

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• Originator

  Dalophylline,Arnolds Veterinary

• Manufacturing Process

  One mol of theophylline was dissolved in a 1% aqueous solution of 1 mol of caustic soda. One mol of β-diethylaminoethyl chloride was added, and the mixture was boiled for 6 hours with reflux, while stirring.
  The product was evaporated to dryness in vacuum, and the dry, pasty residue was taken up in acetone, to separate the desired compound from sodium chloride associated therewith. The acetone solution was distilled to remove solvent and 1,3-dimethyl-7-(β-diethylamino)ethylxanthine-7-(β- (diethylamino)ethyl)theophylline was obtained as a white mass. MP: 74°C. The product is very soluble in water, alcohol and acetone.

• Therapeutic Function

  Diuretic, Cardiotonic, Smooth muscle relaxant, Respiratory stimulant

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