JAK3 INHIBITOR VI

JAK3 INHIBITOR VI 화학적 특성, 용도, 생산

• 일반 설명

  A cell-permeable, potent, and reversible inhibitor of Janus kinase 3 (JAK3) (IC₅₀ = 27 nM). Reported to bind to the enzyme active site and prevent IL-2-induced phosphorylation of JAK3 and STAT5. Also reported to inhibit IL-2-induced cell proliferation (IC₅₀ = 760 nM for murine CTLL cells and 250 nM for human T-cells). Shown to alleviate oxazolone-induced ear edema in mice with an efficacy comparable to Dexamethasone (Cat. No. 265005) and displays ~16-fold greater selectivity over JAK2.

• Biochem/physiol Actions

  Cell permeable: yes

JAK3 INHIBITOR VI 공급 업체

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