ILOPROST

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Danger

• 유해·위험 문구

  H311：피부와 접촉하면 유독함

  H331：흡입하면 유독함

  H361：태아 또는 생식능력에 손상을 일으킬 것으로 의심됨

• 예방조치문구

  P260：분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.

  P262：눈, 피부, 의복에 묻지 않도록 하시오.

  P280：보호장갑/보호의/보안경/안면보호구를 착용하시오.

  P403+P233：용기는 환기가 잘 되는 곳에 단단히 밀폐하여 저장하시오.

ILOPROST 화학적 특성, 용도, 생산

• 개요

  Iloprost is a stable epoprostenol derivative which acts as an inhibitor of platelet aggregation and is recommended for the treatment of peripheral vascular diseases. The compound was shown to be a potent agonist at PGE₂-sensitive and prostacyclin-sensitive receptors in animal studies. Iloprost is administered by IV infusion and has been reported to have beneficial effects in Buerger's and Raynaud's diseases as well as peripheral artery occlusive disease.

• 화학적 성질

  Colourless Oil

• 정의

  ChEBI: A carbobicyclic compound that is prostaglandin I2 in which the endocyclic oxygen is replaced by a methylene group and in which the (1E,3S)-3-hydroxyoct-1-en-1-yl side chain is replaced by a (3R /stereo>)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl group. A synthetic analogue of prostacyclin, it is used as the trometamol salt (generally by intravenous infusion) for the treatment of peripheral vascular disease and pulmonary hypertension.

• 건강위험

  Exposures to quinine vapor are highly irritating to the eyes and may be followed by corneal opacities, structural changes in the cornea, and loss of vision. Solid quinone may produce discoloration, severe irritation, swelling, and form papules and vesicles.

• 생물학적 활성

  Prostacyclin (PGI 2 ) analog that binds with high affinity to IP, EP 1 and EP 3 receptors (K i values are 11, 11, 56, 284, 619, 1035, 1870 and 6487 nM for IP, EP 1 , EP 3 , EP 4 , FP, DP, EP 2 and TP receptors respectively). Inhibits platelet aggregation induced by collagen, thrombin and ADP (IC 50 values are 0.24, 0.71 and 1.07 nM respectively).

ILOPROST 준비 용품 및 원자재

ILOPROST 공급 업체

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