Ginsenoside Rh2

한글명:Ginsenoside Rh2

카스 번호78214-33-2

상품명:Ginsenoside Rh2

CBNumberCB3728899

분자식C36H62O8

포뮬러 무게622.88

MOL 파일78214-33-2.mol

화학적 성질

녹는점	139-144 °C
끓는 점	726.4±60.0 °C(Predicted)
밀도	1.19±0.1 g/cm3(Predicted)
저장 조건	Inert atmosphere,2-8°C
용해도	DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
물리적 상태	Solid
산도 계수 (pKa)	12.91±0.70(Predicted)
색상	하얀색
InChIKey	CKUVNOCSBYYHIS-IRFFNABBSA-N
LogP	5.620 (est)
CAS 데이터베이스	78214-33-2(CAS DataBase Reference)

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

안전지침서

24/25

WGK 독일

RTECS 번호

LZ5776539

HS 번호

29389090

NFPA 704:

	0
2		0

그림문자(GHS)

Ginsenoside Rh2 화학적 특성, 용도, 생산

개요
Ginsenoside Rh₂ is a steroid glycoside found in plants of the genus Panax that has diverse biological activities. It inhibits release of β-hexosaminidase from RBL-2H3 cells (IC₅₀ = 100 μM) and inhibits the IgE-dependent passive cutaneous anaphylaxis reaction in mice at a dose of 25 mg/kg. It inhibits growth of HRA ovarian and BxPC-3 pancreatic cancer cells in a dose-dependent manner. In vivo, ginsenoside Rh₂ decreases immobility time in the forced swim test in a mouse model of colorectal carcinoma. Ginsenoside Rh₂ also reduces infarct volume in a rat model of ischemia-reperfusion-induced brain injury.
화학적 성질
White solid
용도
20(S)-Ginsenoside Rh2 is a bioactive metabolite of the ginsenoside component of Panax ginseng that has been shown to exhibit antibacterial effects in vitro.
정의
ChEBI: A ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy group at position 3 has been converted to the corresponding beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position.
생물학적 활성
Ginsenoside-Rh2, a plant glycosidewith a dammarane skeleton, has been shown to induce apoptosis in a caspase 3,8-dependent manner or the activation of cyclinA-Cdk2 by caspase 3-mediated cleavage of p21(WAF1/CIP1). Also, ginsenoside-Rh2 was shown to inhibit proliferation by inducing the protein expression of p21 and reducing the protein levels of cyclin D, which resulted in the downregulation of cyclin/Cdk complex kinase activity, a reduction in phosphorylation of pRb and the inhibition of E2F release or modulation of MAP kinases in various cancer cells[1].

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