N-오메가-프로필-L-아르기닌

N-오메가-프로필-L-아르기닌 화학적 특성, 용도, 생산

• 개요

  N^ω-Propyl-L-Arginine is a potent and selective inhibitor of neuronal nitric oxide synthase (nNOS). N^ω-Propyl-L-Arginine is a competitive inhibitor of bovine nNOS having a K_i value of 57 nM. The K_i values for eNOS (bovine) and iNOS (murine) are 8.5 and 180 μM, respectively. N^ω-propyl-L-Arginine therefore exhibits 3,000-fold and 150-fold selectivity for the neuronal isoform versus the inducible (murine) and endothelial (bovine) isoforms of NOS, respectively.

• 화학적 성질

  Off-White Solid

• 용도

  A highly selective competitive inhibitor and inactivator of all three isoforms of NOS.

• 생물학적 활성

  Highly selective and potent inhibitor of nNOS (K i = 57 nM). Displays 3158-fold and 149-fold selectivity over iNOS and eNOS respectively. Hypotensive in vivo .

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