6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H315：피부에 자극을 일으킴

  H319：눈에 심한 자극을 일으킴

  H335：호흡 자극성을 일으킬 수 있음

• 예방조치문구

  P305+P351+P338：눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid 화학적 특성, 용도, 생산

• 개요

  PF-06409577 is an activator of AMP-activated protein kinase (AMPK) heterotrimers (K_d = 9 nM for α1β1γ1). In vitro, it selectively activates β1-containing AMPK isoforms (EC₅₀s = 2.18-7.03 nM) over β2-containing isoforms (EC₅₀s = ≥10 μM). PF-06409577 has an EC₅₀ value of 7 nM in an activation/protection TR-FRET assay using α1β1γ1 AMPK. In vivo, PF-06409577 (≥10 mg/kg) increases phosphorylation of AMPK in rat kidney. It decreases urinary albumin levels in a ZSF1 obese rat model of diabetes, metabolic syndrome, and renal disease when administered at a dose of 100 mg/kg.

• 용도

  PF-06409577 has been used to determine its potential as a therapeutic agent for diabetic nephropathy.

• 일반 설명

  PF-06409577 is a 6-chloro-indole derivative obtained from 5-bromo-6-chloro-indole.

6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid 준비 용품 및 원자재

6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid 공급 업체

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