(2E)-N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyanophenyl)-N-[1-(2-cyclopentylethyl)-4-piperidinyl]-2-propenamide

(2E)-N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyanophenyl)-N-[1-(2-cyclopentylethyl)-4-piperidinyl]-2-propenamide 화학적 특성, 용도, 생산

• 개요

  JNJ-5207787 is an antagonist of the neuropeptide Y (NPY) receptor Y₂ that blocks peptide YY binding (IC₅₀ = 100 nM). It displays 100-fold selectivity for Y₂ over other NPY receptors and has minimal effect on a panel of 50 receptors, ion channels, and transporters, except for sodium channel 2. JNJ-5207787 is intraperitoneally bioavailable and brain penetrant in rats, occupying maximally 50% of Y₂ receptor binding sites in the hypothalamic area.

• 용도

  JNJ 5207787 is a small molecule antagonist of the neuropeptide Y Y2 receptor.

(2E)-N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyanophenyl)-N-[1-(2-cyclopentylethyl)-4-piperidinyl]-2-propenamide 공급 업체

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