트리미독스

트리미독스 화학적 특성, 용도, 생산

• 개요

  Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is a common target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation. Trimidox is a specific ribonucleotide reductase inhibitor that reduces levels of dGTP and dCTP in HL-60 cells, inducing apoptosis via activation of caspases without altering the cell cycle distribution. Trimidox inhibits growth of human promyelocytic leukemia HL-60 cells with an IC₅₀ value of 35 μM.

• 용도

  Trimidox is a specific ribonucleotide reductase inhibitor.

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