(15S)-20,21-(Epoxyethano)-15-hydroxy-4-methyl-16-methyleneveatchane

(15S)-20,21-(Epoxyethano)-15-hydroxy-4-methyl-16-methyleneveatchane 화학적 특성, 용도, 생산

• 개요

  This alkaloid occurs in Garrya species and is a major constituent of G. veatchii. It is laevorotatory with [α]^27.5_D - 69.01°. The crystalline hydrochloride has m.p. 2Sl-2°C (dec.); hydrobromide, m.p. 229-2300 C and the hydriodide, m.p. 222-3°C (dec.). The O-acetate has m.p. l52-3°C and yields a hydrochloride, m.p. 258-9°C. The structure has been determined by chemical analysis and from spectroscopic data.

• 참고 문헌

  Wiesneretal., Can. J. Chem., 30,608 (1952)
  Wiesner et al., Ber., 86,800 (1953)
  Wiesner, Edwards., Experientia, 11,255 (1955)
  Vorbrueggen, Djerassi., J. Amer. Chem. Soc., 84, 2999 (1962)
  Nagata et al., ibid, 86,929 (1964)
  Synthesis: Valenta, Wiesner, Wong., Tetrahedron Lett., 2437 (1964)
  Fujita, Fujita, Katayama., Tetrahedron, 26, 1009 (1970)
  Wiesner et al., Experientia, 26, 471 (1970)