(3R)-1-[(20S)-20-(Dimethylamino)-4-oxo-5α-pregnan-3β-yl]-3-isopropylazetidin-2-one

(3R)-1-[(20S)-20-(Dimethylamino)-4-oxo-5α-pregnan-3β-yl]-3-isopropylazetidin-2-one 화학적 특성, 용도, 생산

• 개요

  This alkaloid is the major base found in Pachysandra terminalis Sieb. et Zucco Like the other alkaloids present in this plant, it contains the pregnane skeleton. It is dextrorotatory with [α]D + 24° (CHCI 3). It has two keto groups in the molecule, one being present in a four-membered ring. Reduction with NaBH4 furnishes Pachystermine B (q.v.). The structure has been confirmed by the partial synthesis of the alkaloid.

• 참고 문헌

  Kikuchi, Uyeo., Tetrahedron Lett., 3473 (1965)
  Kikuchi, Uyeo., Chem. Pharm. Bull., 15, 549 (1967)
  Partial synthesis:
  Kikuchi et al., Tetrahedron Lett., 909 (1968)