lannaconitine

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Danger

• 유해·위험 문구

  H300：삼키면 치명적임

• 예방조치문구

  P264：취급 후에는 손을 철저히 씻으시오.

  P264：취급 후에는 손을 철저히 씻으시오.

  P270：이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.

  P301+P310：삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.

  P321：(…) 처치를 하시오.

  P330：입을 씻어내시오.

  P405：밀봉하여 저장하시오.

  P501：...에 내용물 / 용기를 폐기 하시오.

lannaconitine MSDS

• (1a,14a,16b)-20-Ethyl-1,14,16-trimethoxyaconitane-4,8,9-triol 4-(2-acetylamino)benzoate)

lannaconitine 화학적 특성, 용도, 생산

• 개요

  A highly toxic aconitine alkaloid present in Aconitum leucostomum and A. septentrionale Koelle, lappaconitine crystallizes in hexagonal tablets for whichtwo melting points have been recorded. It has [α]_D + 22.3° (C6H6) or [α]¹⁸_D + 27.0° (CHC1 3). The early view that a methylimino group is present has been shown to be erroneous. No crystalline salts are known but the diacetyl derivative forms colourless crystals, m.p. l25-7°C. The base is only sparingly soluble in H20 and most organic solvents, but dissolves readily in CHC1 3.
  Boiling the alkaloid with dilute H2S04 in a stream of H2 yields acetic acid and anthranoyllappaconine, C30H4207N2, which forms colourless rhombic tablets, m.p. 146-9°C;[α]²⁵_D + 22.07° (C6H6), giving a platinichloride tetrahydrate as brown needles, m.p. 300-31 O°C (dec.). When hydrolyzed with HCl, the base furnishes acetic and anthranilic acids and lappaconine, m.p. 96°C; [α]²⁵_D + 22.41°, giving a crystalline hydrochloride, m.p. 246-7°C and the aurichloride monohydrate, m.p. l26-7°C. Alkaline hydrolysis, on the other hand, furnishes lappaconine and lappaconitic acid (acetylanthranilic acid). From these observations, it is clear that only one hydroxyl group is associated with an acyl group in the molecule.
  Pharmacologically, lappaconitine is toxic although its action is less pronounced than that of aconitine (q.v.). Toxic doses produce respiratory paralysis and have a direct action upon the heart often terminating in ventricular fibrillation.

• 참고 문헌

  Schultze, Ulfert., Arch. Pharrn., 260,230 (1922)
  Weidemann., Chern. Zentr., 1,603 (1923)
  Khaimova et al., Tetrahedron Lett., 2711 (1964)
  Structure:
  Tel'nov, Yunusov, Yunusov., Khirn. Prir. Soedin., 6, 583 (1970)
  Pharmacology:
  Rosendahl., quoted by Boehm,!. BioI. Chern., 170,203 (1947)

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