5-(4-클로로페닐)-푸란-2-카르복실산3,5-디메톡시페닐아미드

한글명:5-(4-클로로페닐)-푸란-2-카르복실산3,5-디메톡시페닐아미드

카스 번호944261-79-4

상품명:5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamide

CBNumberCB31471262

분자식C19H16ClNO4

포뮬러 무게357.79

MOL 파일944261-79-4.mol

동의어(한글)

5-(4-클로로페닐)-푸란-2-카르복실산3,5-디메톡시페닐아미드

화학적 성질

녹는점	128-130?C
끓는 점	450.6±45.0 °C(Predicted)
밀도	1.294±0.06 g/cm3(Predicted)
저장 조건	room temp
용해도	DMSO: >10mg/mL
산도 계수 (pKa)	11.72±0.70(Predicted)
물리적 상태	가루
색상	흰색에서 황갈색까지
안정성	제공된 대로 구매일로부터 1년 동안 안정적입니다. DMSO 또는 에탄올 용액은 -20°C에서 최대 3개월 동안 보관할 수 있습니다.

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

WGK 독일

NFPA 704:

	0
2		0

그림문자(GHS)

5-(4-클로로페닐)-푸란-2-카르복실산3,5-디메톡시페닐아미드 화학적 특성, 용도, 생산

개요
Na_v1.8 is a tetrodotoxin-resistant (TTX-R) sodium channel with high activation threshold and slow inactivating kinetics that is highly expressed in small-diameter sensory neurons and has been implicated in signaling various types of pain. A-803467 is a sodium channel blocker with high-affinity and selectivity for inhibiting human Na_v1.8 sodium channels (IC₅₀ = 8 nM when stimulated at half-maximal inactivation and IC₅₀ = 79 nM at a resting state). This compound is unusual in that it blocks hNav1.8 at negative resting membrane potentials (many small molecule sodium channel blockers show a reduced affinity for the resting state) and does not demonstrate significant frequency-dependent block during a 10 Hz pulse train. A-803467 dose-dependently reduces behavioral responses in a variety of neuropathic and inflammatory pain models.
화학적 성질
White Solid
일반 설명
The small molecule A-803467 is a potent and selective Nav1.8 sodium channel blocker. Nav1.8 is a tetrodotoxin-resistant (TTX-R) sodium channel that contributes to pain sensation by transmitting pain stimuli in peripheral sensory neurons; blockage of this channel by A-803467 reduces pain with varying effectiveness in a number of different models. A-803467 has been used to further understand the role of Nav1.8 in transmitting pain stimuli and also can be used as an analgesic.
생물학적 활성
Selective blocker of Na V 1.8 channels (IC 50 values are 8, 2450, 6740, 7340 and 7380 nM for hNa V 1.8, hNa V 1.3, hNa V 1.7, hNa V 1.5 and hNa V 1.2 channels respectively). Shows no significant activity against TRPV1, P2X 2/3 , Ca V 2.2 and KCNQ2/3 channels. Antinociceptive; potently attenuates mechanical allodynia in two models of neuropathic pain following i.p. administration.

5-(4-클로로페닐)-푸란-2-카르복실산3,5-디메톡시페닐아미드 공급 업체

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