포르피센

포르피센 화학적 특성, 용도, 생산

• 효소 저해제

  These synthetic photosensitizers (FW = 310.36 g/mol; CAS 100572-96-1) are Fe (II) - and Fe (III) -binding structural isomers of porphyrin that promote singlet oxygen-mediated photodamage and are used in photodynamic therapy, or PTD (1-3). Their unique solubility and photochemical properties depend on the nature of ring substituents and bound metal ion. Photosensitizers with specific targets (e.g., mitochondria, lysosomes, and plasma membrane) may be used to delineate the mechanism of PDT- induced apoptosis in cancer cells. One example is 9-acetoxy-2,7,12,17- tetrakis- (b-methoxyethyl) -porphycene (ATMPn), which enters cells and concentrates within mitochondria.

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