Androgens

Androgens 화학적 특성, 용도, 생산

• 용도

  Androgens are derivatives of testosterone (29.1.5), methyltestosterone (29.1.7), fluoxymesterone (29.3.5), and testolactone (30.5.1), and are frequently used for palliative treatment of breast cancer in post-menopausal women, for which hormone therapy is used. The exact mechanism of the anticancer effect of androgens is not known. However, it is presumed that androgens block cell growth by inhibiting transport of natural hormone into the cell. Moreover, androgens can inhibit estrogen synthesis, thus depleting estrogen reserves.
  

• World Health Organization (WHO)

  Androgens have been used for the prevention of postpartum breast pain and engorgement. However, because of the risk of rebound effect and since only 10% of women benefit therapeutically from such intervention, the United States Food and Drug Administration has requested manufacturers to stop labeling preparations containing androgens for this indication. The World Health Organization is not aware of similar action having been taken elsewhere.