오로티오글리카나이드

오로티오글리카나이드 화학적 특성, 용도, 생산

• Originator

  Lauron,Endo,US,1945

• Manufacturing Process

  The product is made preferably by reacting thioglycolic acid anilide with an aurous bromide (AuBr).
  Prior art methods for making the starting material, HSCH2CONHC6H5 are disclosed in an article by Beckurts et al. in Journ. Praktische Chemie (2) 66 p. 174, and in the literature referred to in the mentioned article.
  Ten grams of the potassium salt of bromoauric acid are dissolved in 100 cc of 96% ethyl alcohol. This salt is also designated as potassium auribromide. Sulfur dioxide (SO2) is then led through this solution, through a fine capillary tube, for several minutes. This reaction produces aurous bromide (AuBr). The solution of the aurous bromide is then allowed to stand for 2 to 3 hours until it is colorless. A precipitate of KBr is thus formed. This precipitate is separated from the solution of the aurous bromide which is added to a solution of three grams of the thioglycolic acid anilide in 50 cc of ethyl alcohol. This is done at about 20°C. Then 300 cc of water are added to this mixture, at 20°C. The water is then removed by decantation or any suitable method, and the mixture is repeatedly thus treated with water, in order to remove all impurities which can thus be removed. The product is then centrifuged twice with 96% ethyl alcohol. It is then centrifuged three times with 100% or absolute ethyl alcohol, and then centrifuged three times with water-free ligroin (petroleum ether), i.e., the 40-60°C fraction which is distilled from petroleum. After each centrifuging, the product is separated from the liquid which has been used during the centrifuging.
  The product is then dried in a high vacuum with the use of phosphorus pentoxide (P2O5).

• Therapeutic Function

  Antiarthritic

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