조카이논

조카이논 화학적 특성, 용도, 생산

• Originator

  Zocainone,ZYF Pharm Chemical

• Manufacturing Process

  21.0 g of N,N-diethylaminoethyl chloride are added drop by drop to 35.0 g of the sodium salt of 3-o-hydroxyphenoxy-4-phenyl-3-butene-2-one suspended in 600 ml of anhydrous acetone. The mixture is heated under reflux for 4 h, the sodium chloride is filtered off, and the filtrate is evaporated to dryness. The residue is dissolved in water and extracted a number of times with diethyl ether. The ether phase, after drying over Na 2 SO 4 , is evaporated to dryness and purified by distillation in a bulb apparatus, and 3-[o-(β-N,N- diethylaminoethoxy)phenoxy]-4-phenyl-3-buten-2-one was obtained, boiling point 200-210°C/0.6 mm Hg).

• Therapeutic Function

  Antiarrhythmic

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