레미펜타닐염산염

한글명:레미펜타닐염산염

카스 번호132539-07-2

상품명:Remifentanil Hydrochloride

CBNumberCB31105671

분자식C20H28N2O5.ClH

포뮬러 무게412.911

MOL 파일132539-07-2.mol

동의어(한글)

레미펜타닐염산염

화학적 성질

녹는점	195-197°C
인화점	9°C
저장 조건	2-8°C
용해도	PBS (pH 7.2): 10 mg/ml
물리적 상태	A neat solid
CAS 데이터베이스	132539-07-2

위험 및 안전 성명

유엔번호(UN No.)

UN1230 - class 3 - PG 2 - Methanol, solution

WGK 독일

NFPA 704:

	0
4		0

그림문자(GHS)

레미펜타닐염산염 화학적 특성, 용도, 생산

개요
Ultiva was launched in Germany and the US for use in general anesthesia and immediate post-operative pain management. This compound can be prepared via the Michael addition of a 4,4-disubstituted piperidine to methyl acrylate. It behaves as a specific μ-opiod agonist that is about 30 times more potent than its chemical relative alfentanil. While its pharmacodynamic properties are similar to other μ agonists, remifentanil has unique pharmacokinetic properties. It has a rapid onset (1.6 min) and a rapid offset (5.4 min) independent of duration of administration. This has been attributed to its rapid catabolism by general esterases to the corresponding acrylic acid derivative. The metabolite has 0.01 to 0.0005 times the activity of remifentanil and is excreted via the kidneys (80% recovery).
화학적 성질
White Solid
용도
Labelled synthetic mu-opioid agonist. This is a controlled substance (opiate)
Pharmacokinetics
Remifentanil is much like alfentanil in its pharmacodynamic effects. It is a selective μ opioid agonist with 15 to 20 times greater potency than alfentanil. Remifentanil has an onset of action of 1 to 3 minutes when given intravenously. Its unique property is its rapid offset of action, which is independent of the duration of administration of the compound. Thus, it is very useful for titration of antinociceptive effect, followed by a rapid and predictable recovery time of 3 to 5 minutes. The short duration of action is a result of the ester group, which has been rationally designed into the substituent on the piperidine nitrogen. This ester group is rapidly hydrolyzed to the inactive carboxylic acid by serum and tissue esterases, making the drug's duration of action essentially independent of the liver or renal function of the patient. Remifentanil is used extensively for analgesia associated with general anesthesia procedures. It often is used in combination with injectable general anesthetic agents, such as midazolam or propofol.

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