페놀프탈레인이인산사나트륨

한글명:페놀프탈레인이인산사나트륨

카스 번호724709-68-6

상품명:PHENOLPHTHALEIN DIPHOSPHATE TETRASODIUM

CBNumberCB2973067

분자식C21H18O4

포뮬러 무게334.37

MOL 파일724709-68-6.mol

동의어(한글)

페놀프탈레인이인산사나트륨

화학적 성질

녹는점	98 °C(Solv: methanol (67-56-1); water (7732-18-5))
끓는 점	537.7±50.0 °C(Predicted)
밀도	1.246±0.06 g/cm3(Predicted)
저장 조건	2-8°C
용해도	DMSO: 용해성10mg/mL, 투명
물리적 상태	가루
색상	흰색에서 베이지색

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

36/37/38

안전지침서

26-36

WGK 독일

NFPA 704:

	0
2		0

그림문자(GHS)

페놀프탈레인이인산사나트륨 화학적 특성, 용도, 생산

개요
Psora 4 is an inhibitor of voltage-gated potassium channels (K_v1.3; EC₅₀ = 3 nM). It is selective for K_v1.3 over K_v1.1, K_v1.2, K_v1.4, K_v1.7, and K_v3.1 channels (EC₅₀s = 62, 49, 202, 100, and 1,500 nM, respectively) but does inhibit the K_v1.5 channel (EC₅₀ = 7.7 nM). Psora 4 selectively binds to the C-type inactivated state of the K_v1.3 channel and inhibits potassium current in a use-dependent manner. It has immunosuppressive activity, inhibiting proliferation of human and rat myelin-specific effector memory T cells in vitro (TEM cells; EC₅₀s = 25 and 60 nM, respectively).
용도
Psora-4 is the most potent small-molecule Kv1.3 blocker known. Psora-4 and other Kv1.3 blockers may be useful as immunomodulators for the therapy of autoimmune disorders.
Biochem/physiol Actions
The lymphocyte potassium channel Kv1.3 is regarded as a new target for immunosuppression. Psora-4 is the most potent small-molecule Kv1.3 blocker known. It blocked Kv1.3 in a use-dependent manner, with a Hill coefficient of 2 and an EC50 value of 3 nM, by preferentially binding to the C-type inactivated state of the channel. It exhibited 17- to 70-fold selectivity for Kv1.3 over closely related Kv1-family channels (Kv1.1, Kv1.2, Kv1.4, and Kv1.7) with the exception of Kv1.5 (EC50, 7.7 nM) and showed no effect on human ether-a-go-go-related channel, Kv3.1, the calcium-activated K+ channels (IKCa1, SK1-SK3, and BKCa), or the neuronal NaV1.2 channel. In a test of in vivo toxicity in rats, Psora-4 did not display any signs of acute toxicity after five daily subcutaneous injections at 33 mg/kg body weight. Psora-4 selectively suppressed the proliferation of human and rat myelin-specific effector memory T cells with EC50 values of 25 and 60 nM, respectively, without persistently suppressing peripheral blood naive and central memory T cells. Because autoantigen-specific effector memory T cells contribute to the pathogenesis of T cell-mediated autoimmune diseases such as multiple sclerosis, Psora-4 and other Kv1.3 blockers may be useful as immunomodulators for the therapy of autoimmune disord.

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