아다멕신

아다멕신 화학적 특성, 용도, 생산

• Originator

  Adamexine ,ZYF Pharm Chemical

• Manufacturing Process

  4.3 g 2-brommemtyl-4,6-dibromo-N,N-diacetylaniline and 1.65 g Nmethyladamantyl amine in 100 ml of absolute ethanol were heated to reflux for 8 hours. The ethanol was removed and a residue was washed with some times with ether. The resulting hard mass was refluxed with 150 ml 2 N HCl for 2 hours. The obtained product was cooled and stood for 10-12 hours at 4°C in a refrigerator. The crystalline 2-(N-(1-adamantyl)-Nmethylaminomethyl- 4',6'-dibromacetanilid hydrochloride (adamexine) was filtered off and thoroughly washed with distilled water. It was recrystallized from a mixture glacial acetic acid/water 2:1 (v/v) to give a white crystalline powder, melting at 250°-254°C. The hydrochloride is better for a pharmaceutical composition because of solubility in water. The free base may be prepared by adding of an equivalent of any basic compound (NaOH, NaHCO3 and so on).

• Therapeutic Function

  Mucolytic

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