네라티닙

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Danger

• 유해·위험 문구

  H290：금속을 부식시킬 수 있음

  H314：피부에 심한 화상과 눈에 손상을 일으킴

• 예방조치문구

  P234：원래의 용기에만 보관하시오.

  P264：취급 후에는 손을 철저히 씻으시오.

  P264：취급 후에는 손을 철저히 씻으시오.

  P280：보호장갑/보호의/보안경/안면보호구를 착용하시오.

  P301+P330+P331：삼켰다면 입을 씻어내시오. 토하게 하려 하지 마시오.

  P303+P361+P353：피부(또는 머리카락)에 묻으면 오염된 모든 의복은 벗거나 제거하시오 피부를 물로 씻으시오/샤워하시오.

  P363：다시 사용전 오염된 의류는 세척하시오.

  P390：물질손상을 방지하기 위해 누출물을 흡수시키시오.

  P405：밀봉하여 저장하시오.

  P406：부식을 방지하여 보관하시오/...내부식성 용기

네라티닙 화학적 특성, 용도, 생산

• 개요

  The receptor tyrosine kinase HER2 (ErbB2) is a key component of epidermal growth factor receptor complexes that are known to have central roles in cell proliferation and cancer. Neratinib is an orally active, irreversible inhibitor of the HER2 kinase (IC₅₀ = 59 nM). It also potently inhibits several mutants of HER2 and shows 10-fold or greater selectivity over a wide variety of other kinases. As an irreversible inhibitor, neratinib may circumvent acquired resistance developed against reversible inhibitors, including gefitinib . Neratinib has been evaluated in clinical trials against cancers characterized by HER2 overexpression or HER2 activating mutations.

• Characteristics

  Class: receptor tyrosine kinase
  Treatment: HER2-positive breast cancer
  Elimination half-life = 14.6 h
  Protein binding = 99%

• 용도

  Neratinib (HKI-272) is a highly selective HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM, respectively.

• 정의

  ChEBI: A quinoline compound having a cyano group at the 3-position, a 3-chloro-4-(2-pyridylmethoxy)anilino group at the 4-position, a 4-dimethylamino-trans-but-2-enamido group at the 6-position, and an ethoxy group at the 7-position.

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