Dioscin

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H315：피부에 자극을 일으킴

  H319：눈에 심한 자극을 일으킴

• 예방조치문구

  P264：취급 후에는 손을 철저히 씻으시오.

  P264：취급 후에는 손을 철저히 씻으시오.

  P280：보호장갑/보호의/보안경/안면보호구를 착용하시오.

  P302+P352：피부에 묻으면 다량의 물로 씻으시오.

  P305+P351+P338：눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

  P332+P313：피부 자극이 생기면 의학적인 조치· 조언을 구하시오.

  P337+P313：눈에 대한 자극이 지속되면 의학적인 조치· 조언를 구하시오.

Dioscin 화학적 특성, 용도, 생산

• 개요

  Dioscin is extracted from Dioscorea nipponica. Rhizoma Dioscoreae Nipponicae is the dry rhizome of this plant. It can be orally used to treat joint pain, arthritis, malaria, and chronic bronchitis. In addition, it can also be used externally to treat sore carbuncle swollen. Rhizoma Dioscoreae Nipponicae is commonly used in the northeast region, Shanxi province, and Shandong province of China.

• 물리적 성질

  Appearance: white powder. Solubility: insoluble in water, petroleum ether, and benzene; soluble in methanol, ethanol, and acetic acid; slightly soluble in acetone and amyl alcohol. Melting point: 294–296℃. Specific optical rotation: ?115° (c?=?0.373, ethanol).

• 역사

  Japanese scientists firstly reported and analyzed the structure of dioscin isolated from the saponins of Japanese Dioscoreaceae. V . However, the biological activities of dioscin have not attracted the interests of scientists until the late 1990s and the beginning of this century. It is now believed that dioscin may have therapeutic effects on reducing blood lipids and protecting the liver, as well as antivirus, antiinflammatory, and antitumor effects. After the implementation of standardization of traditional Chinese medicine, dioscin as the quality control specification of Dioscorea nipponica Makino and other traditional Chinese medicine has attracted more attentions and researches. In China, dioscin tablets have been used to treat hyperlipidemia in the clinical practice. However, no corresponding drugs are available on the market in other countries. In addition, dioscin is also an important predecessor for synthesizing steroid hormones . Dioscorea nipponica Makino, which is used to extract dioscin, primarily comes from wild plants, whose resources are limited.

• Indications

  This drug was recorded in the national standards for chemical drugs, volume 5. Dioscin tablets, containing total dioscin, are used to treat coronary heart disease, coronary insufficiency, as well as control hyperlipidemia.

• Pharmacology

  Studies showed that compound preparations containing dioscin can increase coronary blood flow, reduce myocardial oxygen consumption, and protect myocardial ischemia and ischemia-reperfusion injury, which is beneficial for alleviating myocardial ischemia and angina. In addition, dioscin can regulate the lipid metabolism and improve hemodynamics. Dioscin can also prevent atherosclerosis by reducing serum total cholesterol, triglyceride, low-density lipoprotein, and oxidized lowdensity lipoprotein, reducing the whole blood viscosity and plasma viscosity at high and low shear rates, and relieving arterial wall lipid infiltration and plaque formation. Furthermore, dioscin can reduce liver fat deposition, which may be related to promoting cholesterol secretion metabolism.
  It has also been reported that dioscin can induce the apoptosis of a variety of tumor cells, including gastric cancer cells, breast cancer cells, lung cancer cells, oral squamous cell carcinoma, and cervical cancer cells. The mechanisms are related to reducing the oxidative stress and inhibiting some cellular survival signaling pathways
  Dioscin can induce antioxidant enzymes, lower blood lipids, improve insulin resistance, inhibit the inflammatory response, reduce the damage of alcoholic hepatitis, and decrease the hepatic injury induced by acetaminophen .

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