에스시탈로프람

한글명:에스시탈로프람

카스 번호128196-01-0

상품명:Escitalopram

CBNumberCB2712918

분자식C20H21FN2O

포뮬러 무게324.39

MOL 파일128196-01-0.mol

동의어(한글)

에스시탈로프람

화학적 성질

알파	D +12.33° (c = 1 in methanol)
끓는 점	428.3±45.0 °C(Predicted)
밀도	1.18±0.1 g/cm3(Predicted)
저장 조건	2-8°C
용해도	DMSO에 용해됨
물리적 상태	가루
산도 계수 (pKa)	9.57±0.28(Predicted)
색상	Off-white to light yellow
CAS 데이터베이스	128196-01-0(CAS DataBase Reference)

위험 및 안전 성명

유해 물질 데이터

128196-01-0(Hazardous Substances Data)

NFPA 704:

	3
2		0

그림문자(GHS)

에스시탈로프람 화학적 특성, 용도, 생산

용도
antidepressive;selective serotonin reuptake inhibitor
정의
ChEBI: A 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile that has S-configuration at the chiral centre. It is the active enantiomer of citalopram.
Mechanism of action
Escitalopram is the S-enantiomer of citalopram that binds with high affinity and selectivity to the human SERT equivalent to (±)-citalopram. It has been reported that nearly all the activity resides in the S-enantiomer and that R-citalopram actually counteracts the action of the S-enantiomer. Studies show that escitalopram exhibits twice the activity of citalopram and is at least 27 times more potent than the R-enantiomer. The R-enantiomer inhibits the S-enantiomer at the transporter. Escitalopram's mechanism of action is common to the SSRIs.
Pharmacokinetics
The pharmacokinetics for escitalopram does not exhibit stereoisomer selectivity and, therefore, is similar to that for citalopram. Likewise, it exhibits linear pharmacokinetics so that plasma levels increase proportionately and predictably with increased doses, and its half-life of 27 to 32 hours is consistent with once-daily dosing. It also has been found that R-citalopram is cleared more slowly than the S-enantiomer. Therefore, when the drug is used as a racemic mixture (citalopram), the inactive isomer predominates at steady state. This is an added incentive for use of the enantiomerically pure escitalopram. Escitalopram has negligible effects on CYP isoforms, suggesting a low potential for drug–drug interactions. Escitalopram is indicated for patients with major depressive disorder, generalized anxiety disorder, panic disorder, and social anxiety disorder.

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