디오스제닌

한글명:디오스제닌

카스 번호512-04-9

상품명:Diosgenin

CBNumberCB2685481

분자식C27H42O3

포뮬러 무게414.63

MOL 파일512-04-9.mol

동의어(한글)

디오스제닌

화학적 성질

녹는점	205-208°C
알파	D25 -129° (c = 1.4 in CHCl3)
끓는 점	473.46°C (rough estimate)
밀도	1.0483 (rough estimate)
굴절률	1.4700 (estimate)
저장 조건	2-8°C
용해도	클로로포름: 20mg/mL, 투명, 약간 노란색
물리적 상태	고체
물리적 상태	단단한 모양
산도 계수 (pKa)	15.02±0.70(Predicted)
색상	흰색에서 연한 노란색
optical activity	-12925 (c 1.4, CHCl3)
수용성	클로로포름(50mg/ml), 에탄올(25°C에서 83mg/ml), 물(25°C에서 <1mg/ml), DMSO(25°C에서 <1mg/ml)에 용해됩니다. 그리고 메탄올.
Merck	14,3295
BRN	94582
LogP	6.602 (est)
CAS 데이터베이스	512-04-9(CAS DataBase Reference)
NIST	Diosgenin(512-04-9)

위험 및 안전 성명

위험품 표기	Xi
위험 카페고리 넘버	36/37/38
안전지침서	26-36/37-24/25
WGK 독일	2
RTECS 번호	WH1450000
HS 번호	29329990

그림문자(GHS)

디오스제닌 MSDS

디오스제닌 화학적 특성, 용도, 생산

화학적 성질
White to Off-White Dolid
출처
Primary sources of diosgenin (a steroidal sapogenin) include Smilax China, Rhizoma polygonati, Solanum incanum, Solanum xanthocarpum, Dioscorea villosa, Trigonella foenum graecum (fenugreek), and Dioscorea Linn (wild yams). It is commercially obtained from wild yam tubers and rootstock[1-2].
용도
Aglicone of saponin dioscin. Diosgenin exists in some food supplements and herbal medicines and lowers plasma cholesterol by increasing fecal cholesterol excretion. e and Progesterone.
일반 설명
Diosgenin is a triterpene and a glycone derivative of dioscin. Yams, Trigonella foenum-graecum and Costus speciosus are some of its source.
Anticancer Research
It is a steroidal saponin and legumes and yams are the rich sources of it. It is a notoriousprecursor of several synthetic steroidal drugs. It suppresses growth of cells andinduces apoptosis in human osteosarcoma, colon cancer, and leukemia. Its anticancermechanism is by arresting the cell cycle, disrupting the calcium homeostasis,activating p53, releasing apoptosis inducing factors, and modulating caspase-3activity. It suppresses NF-κB activation induced by TNF as a result of DNA binding,IκBα kinase activation, degradation, phosphorylation, p65 nuclear translocation,and phosphorylation. It suppresses proliferation and invasion and induces apoptosisby downregulation of cFLIP, cyclin-D1, TRAF1, COX-2, c-myc, Bfl-1/A1, BclxL,IAP1, Bcl-2, and MMP-9 (Aggarwal et al. 2008; Raju and Mehta 2008).
Purification Methods
Crystallise diosgenin from acetone, and chromatograph it on Al2O3 and elute with *C6H6/Et2O (9:1), then recrystallise it from MeOH. Its solubility is ~4% in H2O and 5% in CHCl3. The acetate crystallises from AcOH with m 198o; and has [] D 20 -119o (pyridine). [Marker et al. J Am Chem Soc 65 1199 1943. Mazur et al. J Am Chem Soc 82 5889 1960, Beilstein 19 IV 862.]

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