데나토늄 벤조에이트

한글명:데나토늄 벤조에이트

카스 번호3734-33-6

상품명:Denatonium Benzoate

CBNumberCB2674421

분자식C28H34N2O3

포뮬러 무게446.58

MOL 파일3734-33-6.mol

동의어(한글)

벤조산염

데나토늄벤조에이트

데나토늄벤조에이트(DENATONIUMBENZOATE)

화학적 성질

녹는점	164-168 °C (lit.)
끓는 점	555.91°C (rough estimate)
밀도	1.1256 (rough estimate)
증기압	0Pa at 25℃
굴절률	1.5800 (estimate)
인화점	100℃
저장 조건	Inert atmosphere,Room Temperature
용해도	메탄올: 50 mg/mL, 투명, 무색
물리적 상태	고체
물리적 상태	단단한 모양
색상	흰색에서 황백색까지
냄새	100.00?%. 온화한
수용성	42.555g/L at 25℃
Merck	14,2891
BRN	8179408
안정성	안정적인. 강한 산화제와 호환되지 않습니다.
InChIKey	VWTINHYPRWEBQY-UHFFFAOYSA-N
LogP	2.2 at 25℃
CAS 데이터베이스	3734-33-6(CAS DataBase Reference)
EPA	Denatonium benzoate (3734-33-6)

위험 및 안전 성명

위험품 표기

Xn,Xi

위험 카페고리 넘버

22-36/37/38-20/21/22

안전지침서

26-36-37/39

WGK 독일

RTECS 번호

BO6650000

TSCA

Yes

HS 번호

29242995

NFPA 704:

	0
4		0

그림문자(GHS)

데나토늄 벤조에이트 MSDS

데나토늄 벤조에이트 화학적 특성, 용도, 생산

화학적 성질
white crystals
생산 방법
Denatonium benzoate was first synthesized in the 1950s and is usually prepared by reacting denatonium chloride with benzyl benzoate.
Pharmaceutical Applications
Denatonium benzoate is among the most bitter of substances known and is detectable at concentrations of approximately 10 ppb. In pharmaceutical and other industrial applications it is added to some products as a deterrent to accidental ingestion. It is most commonly used at levels of 5–500 ppm. Denatonium benzoate may also be used to replace brucine or quassin as a denaturant for ethanol.
In pharmaceutical formulations, denatonium benzoate has been used as a flavoring agent in placebo tablets, and in a topical formulation it has been used in an anti-nailbiting preparation.
Safety
Denatonium benzoate is generally regarded as a nonirritant and nonmutagenic substance.However,therehasbeenasinglereportof contact urticaria attributed to denatonium benzoate occurring in a 30-year-old man who developed asthma and pruritus after using an insecticidal spray denatured with denatonium benzoate.
LD50 (rabbit, oral): 0.508g/kg
LD50 (rat, oral): 0.584g/kg
Synthesis
A method for synthesizing Denatonium Benzoate comprises the following steps: (1) adding benzyl halide to a reactor containing raw material lidocaine under stirring and at a certain temperature, wherein the reaction temperature is from room temperature to 130°C, and the ratio of lidocaine to benzyl halide is 1:1 to 1:2; (2) after the reaction is complete, adding solvent and metal hydroxide; (3) adding benzoic acid, after the reaction is completed, the generated benzyl ammonium benzoate is filtered, washed, concentrated, and washed to obtain the product benzyl ammonium benzoate.
저장
Denatonium benzoate is stable up to 140°C and over a wide pH range. It should be stored in a well-closed container (such as polythene-lined steel) in a cool, dry place. Aqueous or alcoholic solutions retaintheir bitterness forseveral years evenwhenexposed to light.
비 호환성
Denatonium benzoateis incompatible with strongoxidizing agents.
Regulatory Status
Denatonium benzoate is used worldwide as a denaturant for alcohol. It is included in the FDA Inactive Ingredients Database (topical gel and solution).

데나토늄 벤조에이트 준비 용품 및 원자재

데나토늄 벤조에이트 공급 업체

데나토늄 벤조에이트 관련 검색

Send Inquriy