Ibutilide fumarate

한글명:Ibutilide fumarate

카스 번호122647-32-9

상품명:Ibutilide fumarate

CBNumberCB2511478

분자식(C20H36N2O3S)2.C4H4O4

포뮬러 무게885.24

MOL 파일122647-32-9.mol

화학적 성질

녹는점	112-117?C
RTECS 번호	PB0475700
저장 조건	2-8°C
용해도	H2O: >20mg/mL
물리적 상태	고체
물리적 상태	단단한 모양
색상	회백색부터 황갈색까지
최대 파장(λmax)	267nm(EtOH)(lit.)
Merck	14,4883
CAS 데이터베이스	122647-32-9(CAS DataBase Reference)

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

WGK 독일

HS 번호

2935904000

독성

rat,LD,oral,> 500mg/kg (500mg/kg),Teratology, The International Journal of Abnormal Development. Vol. 49, Pg. 406, 1994.

NFPA 704:

	0
2		0

그림문자(GHS)

Ibutilide fumarate 화학적 특성, 용도, 생산

개요
Covert was launched in the US and UK for treatment of atrial fibrillation and flutter and can be synthesized in three steps from N-phenyl rnethanesulfonamide. While ibutilide has an asymmetric center, it has been determined that the racemate is equipotent with either enantiomer. The antiarrhythmic action is derived from the compounds ability to prolong the action potential duration and lengthen the refractory period of myocardial tissue. Class Ⅲ antiarrhythrnic agents accomplish this by blocking outward potassium channels, however, ibutilide elicits the same effect by activation of slow inward sodium channels. Recent evidence indicates that it also is a potent blocker of the rapidly acting delayed rectifier potassium current (l_kr)and may block the ATP-inhibited potassium channel.
화학적 성질
White to Off-White Solid
용도
A methanesulfonanilide antiarrhythmic agent; prologns myocardial action potential duration, predominantly by activation of slow inward sodium current. Antiarrhythmic (class III).
Clinical Use
Ibutilide (Corvert) is a structural analog of sotalol and produces cardiac electrophysiological effects similar to those of the antiarrhythmic agents in class III.
Ibutilide is approved for the chemical cardioversion of recent-onset atrial fibrillation and atrial flutter. Ibutilide appears to be more effective in terminating atrial flutter than atrial fibrillation. It can also lower the defibrillation threshold for atrial fibrillation resistant to chemical cardioversion.
부작용
The major adverse effect associated with the use of ibutilide is the risk of torsades de pointes due to QT prolongation. Other reported adverse cardiovascular events (all 2%) include hypotension and hypertension, bradycardia and tachycardia, and varying degrees of A-V block. The incidence of noncardiac adverse events with the exception of nausea does not differ from that of placebo.
Drug interactions
Ibutilide has significant drug interactions.
주의 사항
Contraindications to the use of ibutilide include baseline prolongation of the QT interval, use of other QTprolonging drugs, history of torsades de pointes, hypersensitivity to ibutilide, uncorrected hypokalemia or hypomagnesemia, and pregnancy or breast-feeding.

Ibutilide fumarate 준비 용품 및 원자재

Ibutilide fumarate 공급 업체

Ibutilide fumarate 관련 검색

Send Inquriy